Peripheral Neuropathy

  • Sensory peripheral neuropathies are common and generally do not require neurology input.
  • Establishing cause in primary care
    • The cause of the neuropathy may be clear (e.g. diabetes, alcohol, or medications) and nil else need be done other than addressing this.
  • When there is no cause identified please send the following bloods: FBC, LFTs, U+Es, C-RP, B12 and folate, fasting blood glucose, TFTs, protein electrophoresis and Bence Jones protein. Please note however that in most, no clear cause is found.
  • Are nerve conduction studies required? Neuropathies are a clinical diagnosis. Nerve conduction studies are not required for diagnosis and are also generally unhelpful in establishing cause.

Management

Who to Refer

  • Rapidly progressive neuropathies (i.e. symptoms progressing up limbs over weeks to months)
  • Hand involvement
  • Associated weakness

The above clinical features can be associated with uncommon inflammatory neuropathies, which may require further investigation and management.

Who not to Refer

  • Probable uncomplicated mild axonal peripheral neuropathy symptom.
  • Length dependent (‘glove and stocking’) sensory neuropathies
  • Entrapment syndromes
    • For upper limb entrapment please trial a splint and refer to hand clinic if no improvement.
    • For common peroneal palsy please refer to orthotics. If no improvement or evolution of symptoms, we would be happy to discuss after orthotic input.

How to Refer

SCI Gateway/Neurology