BNP Pathway

NHS Tayside BNP Pathway flowchart and notes

Initial Primary Care Assessment:
  • Where heart failure is suspected perform clinical examination including ECG, chest x-ray, and FBC, U&E, LFT, glucose, TFT, +/- NTproBNP:
    • If normal resting ECG without other clinical features suggestive of heart failure NTproBNP testing is not recommended.
    • If LBBB or significant murmur is present request ECHO directly with ICE without need for BNP. 
    • If patient known to Cardiology department or echo within last 2 years please seek advice before requesting NT proBNP.
    • NT pro BNP results should be treated with caution in the presence of co-morbidity, advanced age - see notes below re interpretation.
    • Note that NTproBNP is now requested via ICE directly (no longer through transthoracic echo request algorithm).

After NTproBNP consider need for ECHO referral:
  • If NTproBNP is less than 400ng/l - heart failure diagnosis unlikely - if normal ECG and no significant murmur ECHO not indicated. 
  • If NTproBNP 400-2000ng/L - consider heart failure as diagnosis, GP request ECHO via ICE, urgency dependent on clinical evaluation. 
  • If NTproBNP >2000ng/L - in absence of other causes heart failure likely, GP request URGENT ECHO via ICE if appropriate, based on clinical evaluation. 

Following ECHO:
Once patient has had ECHO, patient will be triaged directly by heart failure cardiologist to either clinic or advice depending on the result. 

Notes on Interpreting NTproBNP 

  • NTproBNP levels lower in certain conditions:
    • High BMI.
    • In patients already established on heart failure medications. 

  • NTproBNP is higher in certain conditions:
    • Aged over 70 years.
    • Left ventricular hypertrophy, myocardial ischaemia, or tachycardia.
    • Right ventricular overload/pulmonary hypertension/pulmonary embolism.
    • Poor renal function (eGFR less that 60).
    • Infection.
    • Chronic obstructive pulmonary disease (COPD).
    • Diabetes mellitus.
    • Liver impairment.